Abstract: With the traditional control scheme the main steam pressure and the steam temperature of intermediate point cannot be regulated around the target settings when the load of the unit is changing, which will cause severe impacts on the security and efficiency of the unit operation. In this paper, the centralized coordination control scheme based on control-constrained MIMO (multiple input multiple output) predictive control is proposed to resolve the strong coupling and large time delay problems in the MIMO system without extra procedures of decoupling and feedforward. Firstly, the algorithm of control-constrained MIMO predictive control is explored and then prototyped using MATLAB. From the simulation results the centralized coordination control scheme demonstrated comparable tracking performance in power output to the traditional PID control scheme. Nevertheless it outperforms the latter scheme in the aspect of the tracking performance of the main steam pressure and the steam temperature of intermediate point as well as its robustness.