Abstract: The access of large-scale new energy will become a new feature of power systems in the future. At present, the evaluation on the power systems with large-scale new energy (PSLNE) are relatively simple, and can not reflect the differences between regions. The paper firstly analyzes the basic problems of power systems in the future, and then proposes a comprehensive evaluation model considering regional differences. A comprehensive weighting method, which is based on the subjective and objective weighting method, is used to evaluate the reliability, economy, environmental protection and efficiency of power systems. The concept of regional coefficient is introduced and the evaluating indices are differentiated to reflect the regional characteristics. Finally, three representative regions are selected for case study. The evaluation results show that the reliability and environmental protection of electrical power systems shall be given more attentions for the economically developed and densely populated areas, while the economy requirements may be relaxed appropriately for the areas where the power investment is sensitive.